Subject(s)
Humans , Male , Female , Adolescent , Puberty, Delayed/diagnosis , Puberty, Delayed/etiology , Puberty, Delayed/drug therapy , HypogonadismABSTRACT
La pubertad ocurre generalmente entre los 7 y 13 años de edad en las niñas, y entre los 9 y 15 años en los niños, se considera retraso puberal cuando no ha comenzado su desarrollo luego de esta edad. El crecimiento es el proceso fisioló- gico más característico de la infancia y la adoles- cencia, determinado genéticamente en algunos casos y en otros dependerá de la compleja interacción de factores ambientales; un retraso en el diagnóstico puede ocasionar el detrimen- to no solo de la talla y maduración sexual final sino de su salud integral por la falta de un trata- miento oportuno. El presente caso trató de un paciente masculino de 18 años de edad con antecedente de desnutrición y diarrea crónica más síndrome convulsivo secundaria a hipona- tremia, por el cual fue referido; sin embargo desde el punto de vista de crecimiento y desa- rrollo presentaba peso, talla e IMC por debajo del percentil 3 para su edad y características sexuales secundarias no desarrolladas, durante su hospitalización se realizó pruebas hormona- les LH:1.49 mlU/ml, FSH: 8.51 mlU/ml, Testoste- rona: 0.22 ng/ml, Factor de Crecimiento insulini- co tipo 1: 87.30 ng/ml e imágenes Rx de mano y muñeca izquierda que mostró edad ósea de 12 años con 2 meses +/- 2 años DE, los cuales fueron necesarios para definir la enfermedad de base, el diagnóstico clínico de un hipogonadis- mo y retraso puberal en el adulto no son habi- tuales en la práctica médica, hecho en el cual radica la relevancia del caso presentado...(AU)
Subject(s)
Humans , Male , Adolescent , Gonadotropins , Human Development , Hypogonadism/complications , Puberty, Delayed/diagnosisABSTRACT
Introducción: El hipogonadismo hipogonadotrófico asociado a alteraciones del olfato (HHAAO), esuna variante de hipogonadismo hipogonadotrófico, que se asocian a un defecto en la hipófisis o en elhipotálamo, obedeciendo a una falta de hormonas que en condiciones normales estimulan a los ovarioso los testículos.Casos clínicos: Este protocolo se originó a partir de pacientes que consultaron por alteraciones del olfato, desde octubre de 2013 hasta octubre de 2014, de30 pacientes entre 6 a 16 años, se detectaron 3 mujeres menores de 15 años de edad; que presentaron anosmia constatada por olfatometría y ausencia debulbos olfatorios en resonancia magnética nuclear. Una paciente presentó hipoacusia...
Introduction: The hypogonadotropic hypogonadism associated with disturbances of smell (HHAAO),is a variant of hypogonadotropic hypogonadism, which are associated to a defect in thepituitary or hypothalamus, obeying a lack of hormonesthat normally stimulate the ovaries or thetesticles. Clinical case: This originated from patients who consulted for disorders of smell, from October 2013to October 2014, 30 patients aged 6-16 years were detected, 3 women under 15 years of age; they hadanosmia proven by olfactometry and absence of olfactory bulbs in Nuclear Magnetic Resonance. Onepatient had hearing lost...
Introdução: O hipogonadismo hipogonadotrófico associada a distúrbios do olfato (HHAAO), é uma variante de hipogonadismo hipogonadotrófico, que estão associados a um defeito na hipófise ou hipotálamo,obedecendo a uma falta de hormônios que normalmente estimulam os ovários ou os testículos.Caso clínico: Este provenientes de pacientes que consultaram para distúrbios do olfato, a partir de outubro 2013 a outubro de 2014, 30 pacientes comida de entre 6-16 anos foram detectados, três mulheres com menos de 15 anos de idade; eles tinha manosmia comprovada por olfatometria e ausência de bulbos olfatórios em Ressonância Magnética Nuclear.Um paciente apresentou perda auditiva...
Subject(s)
Humans , Adolescent , Female , Child , Olfaction Disorders/diagnosis , Olfaction Disorders/etiology , Clinical Protocols , Developmental Disabilities/diagnosis , Hypogonadism/complications , Hypogonadism/congenital , Hypogonadism/diagnosis , Puberty, Delayed/diagnosis , Kallmann Syndrome/diagnosisABSTRACT
To establish the optimal age of sexual maturation in Egyptian children, Tanner's maturity stages were determined for a sample of children and adolescents [1550 girls, 1563 boys] ranging from 6.5 to 18.5 years. The mean age for attainment of pubic hair [stage PH2] was 10.46 [SD 1.36] years for girls and 11.86 [SD 1.45] years for boys. For axillary hair [stage A2], mean age was 11.65 [SD 1.62] years for girls and 13.55 [SD 1.52] years for boys. The mean age at menarche in girls was 12.44 years and for breast development [stage B2] was 10.71 [SD 1.30] years. Testicular volume by palpation showed that the mean age of genital stage G2 for boys was 10.56 [SD 1.40] years. The study results can aid in the assessment of sexual maturation and pubertal disorders in Egyptian adolescents
Subject(s)
Female , Humans , Male , Age of Onset , Menarche , Breast/growth & development , Testis/growth & development , Puberty, Delayed/diagnosis , Puberty, Precocious/diagnosisSubject(s)
Humans , Male , Female , Child , Adolescent , Puberty, Delayed/diagnosis , Puberty, Delayed/etiologyABSTRACT
The authors have focussed in this article on normal physical growth during puberty and events during adolescence with a brief mention of pubertal disorders.
Subject(s)
Adolescent , Adolescent Health Services , Age Factors , Child , Female , Humans , Male , Puberty/physiology , Puberty, Delayed/diagnosis , Puberty, Precocious/diagnosis , Time FactorsABSTRACT
Delayed puberty associated with short stature can be due to a number of causes. A focused medical history, a directed physical examination and appropriate diagnostic tests are needed to diagnose the underlying cause. A case of an adolescent with delayed puberty and short stature is presented to highlight the diagnostic approach. The most common cause of delayed maturation in adolescents is constitutional delay of puberty, however other causes should also be considered. Treatment for disorders of puberty is determined by the underlying cause
Subject(s)
Humans , Male , Puberty, Delayed/diagnosis , Puberty, Delayed/therapy , Diagnosis, Differential , Body Height , Anthropometry , Age Determination by Skeleton , Kallmann Syndrome , Hormone Replacement Therapy/statistics & numerical dataSubject(s)
Humans , Adolescent , Female , Amenorrhea , Feeding and Eating Disorders/etiology , Nutrition Disorders , Osteoporosis , Puberty, Delayed/etiology , Sports , Sports Medicine , Amenorrhea , Anorexia , Body Image , Bulimia , Feeding and Eating Disorders/diagnosis , Feeding and Eating Disorders/diet therapy , Osteoporosis , Puberty, Delayed/diagnosis , Puberty, Delayed/diet therapyABSTRACT
El objetivo del presente trabajo fue evaluar la infusión de LH-RH y Test de Clorpromazina para mejorar la eficacia diagnóstica diferencial entre Hipogonadismo Hipogonadotrófico (HH) y Retraso Puberal Femenino (RP). Se estudiaron 10 pacientes, 5 HH y 5 RP mediante infusión intravenosa de LH-RH (0,83 µg/min) durante 120 min con dosaje de LH y FSH (IRMA) a los tiempos de 0, 15, 30, 45, 60 y 120 min. A los 7 días se realizó prueba de CPZ (0,33 mg/kg IM) midiendo PRL (IRMA) a los tiempos -15, 0, 30, 60, 90 y 120 min. Durante la infusión de LH-RH los HH mostraron una respuesta máxima de LH (15,56 ñ 4,57 m UI/ml) de menor magnitud que la de los RP (46,00 ñ 20,69 mUI/ml). Esta diferencia fue estadísticamente significativa (p < 0,01) según el test de Mann-Whitney. No se hallaron diferencias estadísticamente significativas en el basal de LH ni en ninguno de los valores de FSH ni de PRL en la prueba de CPZ entre ambos grupos. Conclusiones: * El aumento de LH en respuesta a la infusión de LH-RH permitió discriminar RP de HH. * Si bien no se encontró superposición de valores entre ambos grupos, esto debería confirmarse con un mayor número de casos. * La evaluación del eje prolactínico con CPZ no permitió discriminar los HH de los RP femeninos
Subject(s)
Humans , Female , Adolescent , Adult , Chlorpromazine , Clinical Laboratory Techniques , Diagnosis, Differential , Gonadotropin-Releasing Hormone , Hypogonadism/diagnosis , Immunoradiometric Assay , Prolactin , Puberty, Delayed/diagnosis , Calcification, Physiologic , Follicle Stimulating Hormone/blood , Hypogonadism/classification , Hypogonadism/etiology , Luteinizing Hormone/blood , Prolactin/blood , Puberty, Delayed/etiology , Puberty, Delayed/physiopathologyABSTRACT
We studied the changes in plasma levels of prolactin after an intramuscular injection of 0,33 mg/kg chlorpromazine and changes in plasma levels of LH and FSH after the injection of 100 µg iv GnRH in 16 patients with constitutional delayed puberty, 10 patients with hypogonadotrophic hypogonadism and 6 healthy controls. Prolactin response was significantly lower in patients with hypogonadotrophic hypogonadism compared to subjects with constitutional delayed and healthy controls ( prolactin 7.05ñ1.7, 28.9ñ2.7 and 22.0ñ3.4 ng/ml respectively). LH response to GnRH was also lower in patients with hypogonadotrophic hypogonadism, compared to the other groups ( LH 4.3ñ2.5, 13.4ñ5.4 and 17.2ñ4.8 mUI/ml respectively) however, there was a great overlapping of values. No differences between groups were observed in responses of FSH, testosterone and estrogens to GnRH. It is concluded that prolactin response to chlorpromazine is useful in the differential diagnosis of constitutional delayed puberty
Subject(s)
Humans , Male , Female , Adolescent , Prolactin , Chlorpromazine , Hypogonadism/diagnosis , Puberty, Delayed/diagnosis , Luteinizing Hormone/drug effects , Gonadotropin-Releasing Hormone , Diagnosis, Differential , Gonadal Steroid HormonesABSTRACT
Se revisa la fisiología de la maduración sexual, desde la vida intrauterina hasta la pubertad, con énfasis en los eventos que ocurren durante la pubertad tanto en la mujer como en el varón. Luego se describen las alteraciones que ocurren en el desarrollo de la pubertad: pubertad precoz y pubertad tardía , sus causas, metodología diagnóstica y posibilidades tarapéuticas. Y, en la tercera parte del artículo se comentan las variaciones normales de la pubertad: adrenarquia prematura, telarquia prematura, menarquia prematura y ginecomastia puberal.
Subject(s)
Humans , Male , Female , Puberty/physiology , Puberty, Precocious/classification , Puberty, Precocious/diagnosis , Puberty, Precocious/therapy , Gynecomastia/diagnosis , Gynecomastia/physiopathology , Gynecomastia/therapy , Sexual Maturation/physiology , Puberty, Delayed/classification , Puberty, Delayed/diagnosis , Puberty, Delayed/therapyABSTRACT
This review is focused on the diagnosis, clinical and general therapeutic approach of constitutional growth and puberty delay and hypogonadotrophic hypogonadism in males, 2 entities that are difficult to distinguish. Clinical history and physical examination must be carefully performed. Delayed puberty is due to constitutional growth and puberty delay in the vast majority children. These must be distinguish from a small fraction of boys with hypogonadism, a pathological condition. A number of laboratory test allow the prediction of puberty onset and progression. Nevertheless, the advent of highly sensitive immnuessay and radiometric immunoassay systems for LH, FSH and testosterone has not entirely solved the problem, since their values may overlap between normal and pathological conditions